가토 두개골 결손부 모델에서 테트라사이클린 함유 실크 파이브로인 차폐막의 골유도 재생 효과
The Effects of Tetracycline-loaded Silk Fibroin Membrane on Guided Bone Regeneration in a Rabbit Calvarial Defect Model
이상운, 박용태, 김성곤, 권해용, 조유영, 이희삼,
소속 상세정보
이상운 ( Lee Sang-Woon ) - 강릉원주대학교 치과대학 구강악안면외과학교실
박용태 ( Park Yong-Tae ) - 강릉원주대학교 치과대학 구강악안면외과학교실
김성곤 ( Kim Seong-Gon ) - 강릉원주대학교 치과대학 구강악안면외과학교실
권해용 ( Kweon Hae-Yong ) - 농촌진흥청
조유영 ( Jo You-Young ) - 농촌진흥청
이희삼 ( Lee Heui-Sam ) - 농촌진흥청
KMID : 0360120120340050293
Abstract
Purpose: The aim of this study was to evaluate the bone regeneration ability of 1% tetracycline (TC)-loaded silk fibroin membrane (SFM), in a rabbit calvarial defect model.
Methods: Twenty New Zealand white rabbits were used for this study. Bilateral round defects were made on the rabbit parietal bone, using trephine bur with an 8 mm diameter. TC-loaded SFM or SFM was covered on the right parietal bone defect, and the left parietal bone defects were uncovered for the control. The animals were humanely sacrificed at 4 or 8 weeks postoperatively. A micro-computerized tomography (${\mu}$ 수식 이미지-CT) of each specimen was taken for analysis of bone regeneration. Hematoxylin and Eosin stain were done to observe histological findings.
Results: From the ${\mu}$ 수식 이미지-CT results, regenerated bone volume ($mm^3$ 수식 이미지) of 1% TC-loaded SFM, SFM, and control were $7.80{\pm}5.87$ 수식 이미지, $8.79{\pm}3.44$ 수식 이미지, and $10.61{\pm}5.3$ 수식 이미지 at 4 weeks postoperatively, respectively (P>0.05). Regenerated bone volume ($mm^3$ 수식 이미지) of 1% TC-loaded SFM, SFM, and control were $36.56{\pm}8.50$ 수식 이미지, $25.86{\pm}8.17$ 수식 이미지, and $19.09{\pm}5.07$ 수식 이미지 at 8 weeks postoperatively, respectively (P<0.05).
Conclusion: The 1% TC-loaded SFM showed more bone regeneration than the SFM and the uncovered control, in guided bone regeneration.
키워드
Tetracycline;Silk fibroin;Guided bone regeneration
원문 및 링크아웃 정보
등재저널 정보